Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice

The tumour suppressor gene, TES, is frequently methylated in many human tumours. Previously, we demonstrated that TES promoter methylation and transcriptional silencing was the most common molecular abnormality detected in childhood acute lymphoblastic leukaemia (ALL). Trp53-mutant mouse models pred...

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Detalles Bibliográficos
Autores principales: Weeks, Robert J., Ludgate, Jackie L., Le Mée, Gwenn, Khanal, Rubina, Mehta, Sunali, Williams, Gail, Slatter, Tania L., Braithwaite, Antony W., Morison, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530732/
https://www.ncbi.nlm.nih.gov/pubmed/33004921
http://dx.doi.org/10.1038/s41598-020-73229-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530732/
https://www.ncbi.nlm.nih.gov/pubmed/33004921
http://dx.doi.org/10.1038/s41598-020-73229-3

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