KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1 driver oncofusions and is a biologically and...

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Detalles Bibliográficos
Autores principales: Sobral, Lays M., Hicks, Hannah M., Parrish, Janet K., McCann, Tyler S., Hsieh, Joseph, Goodspeed, Andrew, Costello, James C., Black, Joshua C., Jedlicka, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530783/
https://www.ncbi.nlm.nih.gov/pubmed/32697014
http://dx.doi.org/10.1002/1878-0261.12769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530783/
https://www.ncbi.nlm.nih.gov/pubmed/32697014
http://dx.doi.org/10.1002/1878-0261.12769

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