Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death

Dipyridamole, an antiplatelet drug, has been shown to synergize with statins to induce cancer cell‐specific apoptosis. However, given the polypharmacology of dipyridamole, the mechanism by which it potentiates statin‐induced apoptosis remains unclear. Here, we applied a pharmacological approach to i...

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Detalles Bibliográficos
Autores principales: Longo, Joseph, Pandyra, Aleksandra A., Stachura, Paweł, Minden, Mark D., Schimmer, Aaron D., Penn, Linda Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530792/
https://www.ncbi.nlm.nih.gov/pubmed/32749766
http://dx.doi.org/10.1002/1878-0261.12775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530792/
https://www.ncbi.nlm.nih.gov/pubmed/32749766
http://dx.doi.org/10.1002/1878-0261.12775

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