Cargando…
Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death
Dipyridamole, an antiplatelet drug, has been shown to synergize with statins to induce cancer cell‐specific apoptosis. However, given the polypharmacology of dipyridamole, the mechanism by which it potentiates statin‐induced apoptosis remains unclear. Here, we applied a pharmacological approach to i...
Autores principales: | Longo, Joseph, Pandyra, Aleksandra A., Stachura, Paweł, Minden, Mark D., Schimmer, Aaron D., Penn, Linda Z. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530792/ https://www.ncbi.nlm.nih.gov/pubmed/32749766 http://dx.doi.org/10.1002/1878-0261.12775 |
Ejemplares similares
-
Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases
por: Conti, Marco, et al.
Publicado: (2014) -
Bacterial Cyclic AMP-Phosphodiesterase Activity Coordinates Biofilm Formation
por: Kalivoda, Eric J., et al.
Publicado: (2013) -
Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one
por: Pandyra, Aleksandra, et al.
Publicado: (2014) -
The Biological Effects of Forsythia Leaves Containing the Cyclic AMP Phosphodiesterase 4 Inhibitor Phillyrin
por: Nishibe, Sansei, et al.
Publicado: (2021) -
Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
por: Gao, Juyi, et al.
Publicado: (2015)