A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma

The Notch signaling network determines stemness in various tissues and targeting signaling activity in malignant brain cancers by gamma-secretase inhibitors (GSI) has shown promising preclinical success. However, the clinical translation remains challenging due to severe toxicity side effects and em...

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Detalles Bibliográficos
Autores principales: Herrera-Rios, Dayana, Li, Guanzhang, Khan, Dilaware, Tsiampali, Julia, Nickel, Ann-Christin, Aretz, Philippe, Hewera, Michael, Suwala, Abiagail Kora, Jiang, Tao, Steiger, Hans-Jakob, Kamp, Marcel Alexander, Muhammad, Sajjad, Hänggi, Daniel, Maciaczyk, Jarek, Zhang, Wei, Kahlert, Ulf Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531005/
https://www.ncbi.nlm.nih.gov/pubmed/33004830
http://dx.doi.org/10.1038/s41598-020-72480-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531005/
https://www.ncbi.nlm.nih.gov/pubmed/33004830
http://dx.doi.org/10.1038/s41598-020-72480-y

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