The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the aging brain and is a feature of HD. We soug...

Descripción completa

Detalles Bibliográficos
Autores principales: Machiela, Emily, Jeloka, Ritika, Caron, Nicholas S., Mehta, Shagun, Schmidt, Mandi E., Baddeley, Helen J. E., Tom, Colton M., Polturi, Nalini, Xie, Yuanyun, Mattis, Virginia B., Hayden, Michael R., Southwell, Amber L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531251/
https://www.ncbi.nlm.nih.gov/pubmed/33192449
http://dx.doi.org/10.3389/fnagi.2020.524369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531251/
https://www.ncbi.nlm.nih.gov/pubmed/33192449
http://dx.doi.org/10.3389/fnagi.2020.524369

Ejemplares similares