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OLGenie: Estimating Natural Selection to Predict Functional Overlapping Genes
Purifying (negative) natural selection is a hallmark of functional biological sequences, and can be detected in protein-coding genes using the ratio of nonsynonymous to synonymous substitutions per site (d(N)/d(S)). However, when two genes overlap the same nucleotide sites in different frames, synon...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531306/ https://www.ncbi.nlm.nih.gov/pubmed/32243542 http://dx.doi.org/10.1093/molbev/msaa087 |