Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold

Effective therapies are urgently needed for COVID-19. Here we describe the identification of a new stable human immunoglobulin G1 heavy-chain variable (VH) domain scaffold that was used for the construction of a large library, lCAT6, of engineered human VHs. This library was panned against the recep...

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Detalles Bibliográficos
Autores principales: Sun, Zehua, Chen, Chuan, Li, Wei, Martinez, David R., Drelich, Aleksandra, Baek, Du-San, Liu, Xianglei, Mellors, John W., Tseng, Chien-Te, Baric, Ralph S., Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531518/
https://www.ncbi.nlm.nih.gov/pubmed/32544372
http://dx.doi.org/10.1080/19420862.2020.1778435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531518/
https://www.ncbi.nlm.nih.gov/pubmed/32544372
http://dx.doi.org/10.1080/19420862.2020.1778435

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