Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR

In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated antibody libraries or selection thereof. Here, we pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Simons, Jan Fredrik, Lim, Yoong Wearn, Carter, Kyle P., Wagner, Ellen K., Wayham, Nicholas, Adler, Adam S., Johnson, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531523/
https://www.ncbi.nlm.nih.gov/pubmed/32744131
http://dx.doi.org/10.1080/19420862.2020.1803646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531523/
https://www.ncbi.nlm.nih.gov/pubmed/32744131
http://dx.doi.org/10.1080/19420862.2020.1803646

Ejemplares similares