Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics

Antibody formation to human(ized) therapeutic antibodies in humans is highly skewed toward anti-idiotype responses, probably because the idiotype is the only ‘foreign’ part of the antibody molecule. Here, we analyzed antibody responses to F(ab’)2 fragments of a panel of 17 human(ized) therapeutic an...

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Detalles Bibliográficos
Autores principales: Großerichter-Wagener, Christina, Kos, Dorien, van Leeuwen, Astrid, Dijk, Lisanne, Jeremiasse, Jorn, Loeff, Floris C., Rispens, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531530/
https://www.ncbi.nlm.nih.gov/pubmed/32887534
http://dx.doi.org/10.1080/19420862.2020.1814661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531530/
https://www.ncbi.nlm.nih.gov/pubmed/32887534
http://dx.doi.org/10.1080/19420862.2020.1814661

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