COP9 signalosome is an essential and druggable parasite target that regulates protein degradation

Understanding how the protozoan protein degradation pathway is regulated could uncover new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used the severe diarrhea-causing Entamoeba histolytica...

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Detalles Bibliográficos
Autores principales: Ghosh, Swagata, Farr, Laura, Singh, Aditya, Leaton, Laura-Ann, Padalia, Jay, Shirley, Debbie-Ann, Sullivan, David, Moonah, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531848/
https://www.ncbi.nlm.nih.gov/pubmed/32960936
http://dx.doi.org/10.1371/journal.ppat.1008952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531848/
https://www.ncbi.nlm.nih.gov/pubmed/32960936
http://dx.doi.org/10.1371/journal.ppat.1008952

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