Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Crystal structures of MexB and of its Escherichia coli homolog AcrB had revealed asymmetric trimers depicting a directional drug...

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Detalles Bibliográficos
Autores principales: Glavier, Marie, Puvanendran, Dhenesh, Salvador, Dimitri, Decossas, Marion, Phan, Gilles, Garnier, Cyril, Frezza, Elisa, Cece, Quentin, Schoehn, Guy, Picard, Martin, Taveau, Jean-Christophe, Daury, Laetitia, Broutin, Isabelle, Lambert, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532149/
https://www.ncbi.nlm.nih.gov/pubmed/33009415
http://dx.doi.org/10.1038/s41467-020-18770-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532149/
https://www.ncbi.nlm.nih.gov/pubmed/33009415
http://dx.doi.org/10.1038/s41467-020-18770-5

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