SIRT1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance

Dysregulation of free acid metabolism is a major contributor to the development of insulin resistance and diabetes. Mitochondrial trifunctional enzyme subunit (MTPα) has a critical role in fatty acid β-oxidation. However, the association between MTPα and insulin resistance is not definitively known....

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Detalles Bibliográficos
Autores principales: Wang, Yan-Mei, Huang, Ting-Lei, Meng, Chao, Zhang, Jia, Fang, Ning-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532168/
https://www.ncbi.nlm.nih.gov/pubmed/33009367
http://dx.doi.org/10.1038/s41419-020-03012-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532168/
https://www.ncbi.nlm.nih.gov/pubmed/33009367
http://dx.doi.org/10.1038/s41419-020-03012-9

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