TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown...

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Detalles Bibliográficos
Autores principales: Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532188/
https://www.ncbi.nlm.nih.gov/pubmed/33009411
http://dx.doi.org/10.1038/s41467-020-18761-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532188/
https://www.ncbi.nlm.nih.gov/pubmed/33009411
http://dx.doi.org/10.1038/s41467-020-18761-6

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