Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices

Generation of bispecific antibodies (bsAbs) requires a combination of compatible binders in formats that support desired functionalities. Here, we report that bsAb-matrices can be generated by Format Chain Exchange (FORCE), enabling screening of combinatorial binder/format spaces. Input molecules fo...

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Detalles Bibliográficos
Autores principales: Dengl, Stefan, Mayer, Klaus, Bormann, Felix, Duerr, Harald, Hoffmann, Eike, Nussbaum, Bianca, Tischler, Michael, Wagner, Martina, Kuglstatter, Andreas, Leibrock, Lea, Buldun, Can, Georges, Guy, Brinkmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532213/
https://www.ncbi.nlm.nih.gov/pubmed/33009381
http://dx.doi.org/10.1038/s41467-020-18477-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532213/
https://www.ncbi.nlm.nih.gov/pubmed/33009381
http://dx.doi.org/10.1038/s41467-020-18477-7

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