Cargando…

Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner

Sirtuin 3 (SIRT3) is a deacetylase involved in the development of many inflammation-related diseases including liver fibrosis. Withaferin A (WFA) is a bioactive constituent derived from the Withania somnifera plant, which has extensive pharmacological activities; however, little is known about the r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Jingya, Chen, Chang, Wang, Jue, Chen, Tingting, Yao, Wenjuan, Yan, Tingdong, Liu, Zhaoguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532400/ https://www.ncbi.nlm.nih.gov/pubmed/33029279 http://dx.doi.org/10.1155/2020/2452848

Ejemplares similares

Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
por: Wang, Yuqin, et al.
Publicado: (2019)

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
por: Wang, Yun-Qian, et al.
Publicado: (2018)

Acetate attenuates kidney fibrosis in an oxidative stress‐dependent manner
por: Kawabata, Chiaki, et al.
Publicado: (2023)

The sirtuins, oxidative stress and aging: an emerging link
por: Merksamer, Philip I., et al.
Publicado: (2013)

Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle
por: Defour, Aurélia, et al.
Publicado: (2012)

Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation
por: Xu, Kaiyue, et al.
Publicado: (2019)

Withaferin a Attenuates Retinal Ischemia-Reperfusion Injury via Akt-Dependent Inhibition of Oxidative Stress
por: Yan, Zheyi, et al.
Publicado: (2022)

Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone
por: Khedgikar, V, et al.
Publicado: (2013)

Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner
por: Zhang, Jingyao, et al.
Publicado: (2018)

Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
por: Yang, Huanjie, et al.
Publicado: (2012)

Withaferin A Effectively Targets Soluble Vimentin in the Glaucoma Filtration Surgical Model of Fibrosis
por: Bargagna-Mohan, Paola, et al.
Publicado: (2013)

Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis
por: Bargagna-Mohan, Paola, et al.
Publicado: (2015)

Implications of Withaferin A in neurological disorders
por: Ram, Natasha, et al.
Publicado: (2020)

Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells
por: Huang, Yong-Hao, et al.
Publicado: (2017)

Correction: Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
por: Yang, Huanjie, et al.
Publicado: (2013)

Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
por: Xia, Yangliu, et al.
Publicado: (2021)

HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent Manner
por: Lopez Lloreda, Claudia, et al.
Publicado: (2022)

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo
por: Challa, Azariyas A., et al.
Publicado: (2012)

Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
por: Maitra, Rangan, et al.
Publicado: (2009)

Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
por: Shiragannavar, Varsha D., et al.
Publicado: (2021)

Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner
por: Zhang, Bei, et al.
Publicado: (2019)

Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1
por: Yan, Jiayi, et al.
Publicado: (2022)

Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
por: Zhou, Zi-Xian, et al.
Publicado: (2022)

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines
por: Bale, Swarna, et al.
Publicado: (2018)

Withaferin A Associated Differential Regulation of Inflammatory Cytokines
por: Dubey, Seema, et al.
Publicado: (2018)

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
por: Koval, Liubov, et al.
Publicado: (2021)

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells
por: Chang, Hsueh-Wei, et al.
Publicado: (2017)

Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner
por: Meier, Raphael P. H., et al.
Publicado: (2019)

Sirtuins and Renal Oxidative Stress
por: Ogura, Yoshio, et al.
Publicado: (2021)

Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner
por: Nakayama, Hiroshi, et al.
Publicado: (2010)

Rosuvastatin exerts cardioprotective effect in lipopolysaccharide-mediated injury of cardiomyocytes in an MG53-dependent manner
por: Zhuang, Jiawei, et al.
Publicado: (2022)

Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells
por: Yu, Tzu-Jung, et al.
Publicado: (2020)

Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake
por: Wang, Xijin, et al.
Publicado: (2014)

Withaferin A attenuates ovarian cancer-induced cardiac cachexia
por: Kelm, Natia Q., et al.
Publicado: (2020)

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
por: Dutta, Rinku, et al.
Publicado: (2019)

Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
por: Behl, Tapan, et al.
Publicado: (2020)

Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation
por: Meena, Ajay Kumar, et al.
Publicado: (2021)

Withaferin A: From Ancient Remedy to Potential Drug Candidate
por: Sultana, Tahira, et al.
Publicado: (2021)

Evaluating anticancer properties of Withaferin A—a potent phytochemical
por: Atteeq, Maushma
Publicado: (2022)

Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice
por: Gupta, Saurabh Kumar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_atg3opduh997uc9dhgvsfku50d