Cargando…

An α(2)-adrenoceptor agonist: Dexmedetomidine induces protective cardiomyocyte hypertrophy through mitochondrial-AMPK pathway

Aims: Dexmedetomidine (Dex) as a highly selective α(2)-adrenoceptor agonist, was widely used anesthetic in perioperative settings, whether Dex induces cardiac hypertrophy during perioperative administration is unknown. Methods: The effects of Dex on cardiac hypertrophy were explored using the transv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weng, Xiaojian, Liu, Hua, Zhang, Xiaodan, Sun, Qianqian, Li, Cheng, Gu, Minglu, Xu, Yanyifang, Li, Shitong, Li, Weiwei, Du, Jianer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532472/ https://www.ncbi.nlm.nih.gov/pubmed/33029088 http://dx.doi.org/10.7150/ijms.47598

Ejemplares similares

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
por: Gursoy, Sinan, et al.
Publicado: (2011)

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
por: Troncoso, Mayarling Francisca, et al.
Publicado: (2021)

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
por: Hernández, Jessica Soto, et al.
Publicado: (2014)

The α(2) Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice
por: Fan, Sumei, et al.
Publicado: (2023)

Dexmedetomidine attenuates sevoflurane-induced neurocognitive impairment through α2-adrenoceptors
por: Zhang, Yufeng, et al.
Publicado: (2021)

β(2)‐Adrenoceptor agonist activity of higenamine
por: Hudzik, Thomas J., et al.
Publicado: (2021)

EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway
por: Cai, Yi, et al.
Publicado: (2015)

Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists
por: Ahmad, Faizzan S., et al.
Publicado: (2023)

A Selective Pharmacophore Model for β(2)-Adrenoceptor Agonists
por: Xing, Rui-Juan, et al.
Publicado: (2009)

Decreased autophagy induced by β(1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis
por: Wang, Li, et al.
Publicado: (2018)

Effects of Neuromuscular Blockages on Entropy Monitoring During Sevoflurane Anesthesia
por: Xing, Yian, et al.
Publicado: (2019)

Alpha-2 adrenoceptor agonists and sepsis: improved survival?
por: Quintin, Luc
Publicado: (2010)

Paradoxical bronchoconstriction caused by β(2)-adrenoceptor agonists
por: Ayed, Khadija, et al.
Publicado: (2020)

Dexmedetomidine Protects Human Cardiomyocytes Against Ischemia-Reperfusion Injury Through α2-Adrenergic Receptor/AMPK-Dependent Autophagy
por: Xiao, Yingying, et al.
Publicado: (2021)

Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
por: Shi, Wenjiao, et al.
Publicado: (2021)

Left ventricular hypertrophy with cardiomyocyte atrophy and extensive interstitial fibrosis: a mitochondrial cardiomyopathy
por: Zhang, Xinyu, et al.
Publicado: (2022)

Structure and Function of an Irreversible Agonist-β(2) Adrenoceptor complex
por: Rosenbaum, Daniel M., et al.
Publicado: (2011)

Functional desensitization of the β(2) adrenoceptor is not dependent on agonist efficacy
por: Rosethorne, Elizabeth M, et al.
Publicado: (2015)

On the Site and Mechanism of Action of β(3)-Adrenoceptor Agonists in the Bladder
por: Andersson, Karl Erik
Publicado: (2017)

The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors
por: Proudman, Richard G. W., et al.
Publicado: (2021)

Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms
por: Li, Yiping, et al.
Publicado: (2019)

Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway
por: Gradinaru, Irina, et al.
Publicado: (2015)

Benzoylaconine improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis
por: Chen, Leijie, et al.
Publicado: (2022)

Decreased autophagy: a major factor for cardiomyocyte death induced by β(1)-adrenoceptor autoantibodies
por: Wang, L, et al.
Publicado: (2015)

Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain
por: Zhang, Pinyi, et al.
Publicado: (2020)

The signaling and selectivity of α‐adrenoceptor agonists for the human α2A, α2B and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors
por: Proudman, Richard G. W., et al.
Publicado: (2022)

Lycopene Inhibits Urotensin-II-Induced Cardiomyocyte Hypertrophy in Neonatal Rat Cardiomyocytes
por: Chao, Hung-Hsing, et al.
Publicado: (2014)

Long-acting β-adrenoceptor agonists in the management of COPD: focus on indacaterol
por: Beier, Jutta, et al.
Publicado: (2011)

Beta3-Adrenoceptor Agonists: Possible Role in the Treatment of Overactive Bladder
por: Igawa, Yasuhiko, et al.
Publicado: (2010)

Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer
por: Modzelewska, Beata, et al.
Publicado: (2016)

Alpha(2)‐adrenoceptor agonists inhibit form‐deprivation myopia in the chick
por: Carr, Brittany J, et al.
Publicado: (2019)

A Clinician’s Perspective on the Mechanism of β(3)-Adrenoceptor Agonists in the Bladder
por: Lee, Tack
Publicado: (2017)

AMPKα2 Overexpression Reduces Cardiomyocyte Ischemia-Reperfusion Injury Through Normalization of Mitochondrial Dynamics
por: Deng, Yuanyan, et al.
Publicado: (2020)

Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway
por: Chen, Youming, et al.
Publicado: (2020)

Mitochondrial Biogenesis, Mitochondrial Dynamics, and Mitophagy in the Maturation of Cardiomyocytes
por: Ding, Qianqian, et al.
Publicado: (2021)

Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice
por: Luo, Su-mei, et al.
Publicado: (2022)

On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists
por: Pattij, Tommy, et al.
Publicado: (2011)

The long-acting β(2)-adrenoceptor agonist olodaterol attenuates pulmonary inflammation
por: Wex, Eva, et al.
Publicado: (2015)

Myristate induces mitochondrial fragmentation and cardiomyocyte hypertrophy through mitochondrial E3 ubiquitin ligase MUL1
por: Vásquez-Trincado, César, et al.
Publicado: (2023)

Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons
por: Im, Sang-Taek, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n9nflsu16rl3k664i16hif4c3o