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Homocysteine aggravates DNA damage by impairing the FA/Brca1 Pathway in NE4C murine neural stem cells

There is existing evidence that elevated homocysteine (Hcy) levels are risk factors for some neurodegenerative disorders. The pathogenesis of neurological diseases could be contributed to excessive cell dysfunction and death caused by defective DNA damage response (DDR) and accumulated DNA damage. H...

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Detalles Bibliográficos
Autores principales: Yan, Yana, Yin, Yandan, Feng, Xiaofang, Chen, Yuan, Shi, Jiamin, Weng, Huachun, Wang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532487/
https://www.ncbi.nlm.nih.gov/pubmed/33029090
http://dx.doi.org/10.7150/ijms.49246