Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy

Chimeric antigen receptor (CAR) T cell therapies, and adoptive cell therapy (ACT) in general, represent one of the most promising anti-cancer strategies. Conditioning has been shown to improve the immune homeostatic environment to enable successful ACT or CAR-T engraftment and expansion in vivo foll...

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Detalles Bibliográficos
Autores principales: Dawicki, Wojciech, Allen, Kevin J.H., Garg, Ravendra, Geoghegan, Eileen M., Berger, Mark S., Ludwig, Dale L., Dadachova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533072/
https://www.ncbi.nlm.nih.gov/pubmed/33062193
http://dx.doi.org/10.18632/oncotarget.27731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533072/
https://www.ncbi.nlm.nih.gov/pubmed/33062193
http://dx.doi.org/10.18632/oncotarget.27731

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