Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

The exchange proteins activated by cAMP (EPAC) are implicated in a large variety of physiological processes and they are considered as promising targets for a wide range of therapeutic applications. Several recent reports provided evidence for the therapeutic effectiveness of the inhibiting EPAC1 ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Bufano, Marianna, Laudette, Marion, Blondeau, Jean-Paul, Lezoualc’h, Frank, Nalli, Marianna, Silvestri, Romano, Brancale, Andrea, Coluccia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533256/
https://www.ncbi.nlm.nih.gov/pubmed/32700175
http://dx.doi.org/10.1007/s10822-020-00332-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533256/
https://www.ncbi.nlm.nih.gov/pubmed/32700175
http://dx.doi.org/10.1007/s10822-020-00332-y

Ejemplares similares