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Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
The exchange proteins activated by cAMP (EPAC) are implicated in a large variety of physiological processes and they are considered as promising targets for a wide range of therapeutic applications. Several recent reports provided evidence for the therapeutic effectiveness of the inhibiting EPAC1 ac...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533256/ https://www.ncbi.nlm.nih.gov/pubmed/32700175 http://dx.doi.org/10.1007/s10822-020-00332-y |