Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...

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Detalles Bibliográficos
Autores principales: Docherty, Craig K., Denver, Nina, Fisher, Simon, Nilsen, Margaret, Hillyard, Dianne, Openshaw, Rebecca L., Labazi, Hicham, MacLean, Margaret R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533346/
https://www.ncbi.nlm.nih.gov/pubmed/33230444
http://dx.doi.org/10.1016/j.omtn.2020.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533346/
https://www.ncbi.nlm.nih.gov/pubmed/33230444
http://dx.doi.org/10.1016/j.omtn.2020.09.002

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