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Emerging insights on the role of gasdermins in infection and inflammatory diseases

The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of cell death. Additionally, gasdermins also act a...

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Autores principales: Tang, Lipeng, Lu, Chuanjian, Zheng, Guangjuan, Burgering, Boudewijn MT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533414/
https://www.ncbi.nlm.nih.gov/pubmed/33033617
http://dx.doi.org/10.1002/cti2.1186
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author Tang, Lipeng
Lu, Chuanjian
Zheng, Guangjuan
Burgering, Boudewijn MT
author_facet Tang, Lipeng
Lu, Chuanjian
Zheng, Guangjuan
Burgering, Boudewijn MT
author_sort Tang, Lipeng
collection PubMed
description The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of cell death. Additionally, gasdermins also act as key effectors of NETosis, secondary necrosis and apoptosis. In this review, we will address current understanding of the mechanisms of gasdermin activation and further describe the protective and detrimental roles of gasdermins in host defence and autoinflammatory diseases. These data suggest that gasdermins play a prominent role in innate immunity and autoinflammatory disorders, thereby providing potential new therapeutic avenues for the treatment of infection and autoimmune disease.
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spelling pubmed-75334142020-10-07 Emerging insights on the role of gasdermins in infection and inflammatory diseases Tang, Lipeng Lu, Chuanjian Zheng, Guangjuan Burgering, Boudewijn MT Clin Transl Immunology Reviews The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of cell death. Additionally, gasdermins also act as key effectors of NETosis, secondary necrosis and apoptosis. In this review, we will address current understanding of the mechanisms of gasdermin activation and further describe the protective and detrimental roles of gasdermins in host defence and autoinflammatory diseases. These data suggest that gasdermins play a prominent role in innate immunity and autoinflammatory disorders, thereby providing potential new therapeutic avenues for the treatment of infection and autoimmune disease. John Wiley and Sons Inc. 2020-10-04 /pmc/articles/PMC7533414/ /pubmed/33033617 http://dx.doi.org/10.1002/cti2.1186 Text en © 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Tang, Lipeng
Lu, Chuanjian
Zheng, Guangjuan
Burgering, Boudewijn MT
Emerging insights on the role of gasdermins in infection and inflammatory diseases
title Emerging insights on the role of gasdermins in infection and inflammatory diseases
title_full Emerging insights on the role of gasdermins in infection and inflammatory diseases
title_fullStr Emerging insights on the role of gasdermins in infection and inflammatory diseases
title_full_unstemmed Emerging insights on the role of gasdermins in infection and inflammatory diseases
title_short Emerging insights on the role of gasdermins in infection and inflammatory diseases
title_sort emerging insights on the role of gasdermins in infection and inflammatory diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533414/
https://www.ncbi.nlm.nih.gov/pubmed/33033617
http://dx.doi.org/10.1002/cti2.1186
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