Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides

MicroRNAs (miRNAs) function cell-intrinsically to regulate gene expression by base-pairing to complementary mRNA targets while in association with Argonaute, the effector protein of the miRNA-mediated silencing complex (miRISC). A relatively dilute population of miRNAs can be found extracellularly i...

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Detalles Bibliográficos
Autores principales: Geekiyanage, Hirosha, Rayatpisheh, Shima, Wohlschlegel, James A., Brown, Robert, Ambros, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533700/
https://www.ncbi.nlm.nih.gov/pubmed/32929008
http://dx.doi.org/10.1073/pnas.2008323117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533700/
https://www.ncbi.nlm.nih.gov/pubmed/32929008
http://dx.doi.org/10.1073/pnas.2008323117

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