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Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides

MicroRNAs (miRNAs) function cell-intrinsically to regulate gene expression by base-pairing to complementary mRNA targets while in association with Argonaute, the effector protein of the miRNA-mediated silencing complex (miRISC). A relatively dilute population of miRNAs can be found extracellularly i...

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Detalles Bibliográficos
Autores principales:	Geekiyanage, Hirosha, Rayatpisheh, Shima, Wohlschlegel, James A., Brown, Robert, Ambros, Victor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533700/ https://www.ncbi.nlm.nih.gov/pubmed/32929008 http://dx.doi.org/10.1073/pnas.2008323117

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