Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM(197) conjugate vaccine

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fraction...

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Detalles Bibliográficos
Autores principales: Micoli, Francesca, Bjarnarson, Stefania P., Arcuri, Melissa, Aradottir Pind, Audur Anna, Magnusdottir, Gudbjorg J., Necchi, Francesca, Di Benedetto, Roberta, Carducci, Martina, Schiavo, Fabiola, Giannelli, Carlo, Pisoni, Ivan, Martin, Laura B., Del Giudice, Giuseppe, MacLennan, Calman A., Rappuoli, Rino, Jonsdottir, Ingileif, Saul, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533886/
https://www.ncbi.nlm.nih.gov/pubmed/32900928
http://dx.doi.org/10.1073/pnas.2005857117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533886/
https://www.ncbi.nlm.nih.gov/pubmed/32900928
http://dx.doi.org/10.1073/pnas.2005857117

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