PSMA-Targeting Reduction-Cleavable Hyperbranched Polyamide-Amine Gene Delivery System to Treat the Bone Metastases of Prostate Cancer

OBJECTIVE: This study aimed to develop aptamer-anchored hyperbranched poly(amido amine) (HPAA) for the systemic delivery of miRNA-133a-3p and to evaluate its therapeutic potential against bone metastasis of prostate cancer in vivo and in vitro. METHODS: A glutathione (GSH)-responsive cationic HPAA w...

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Detalles Bibliográficos
Autores principales: Ye, Yongheng, Zhang, Lingli, Dai, Yuhu, Wang, Zhi, Li, Cuie, Peng, Yue, Ma, Dong, He, Peiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533908/
https://www.ncbi.nlm.nih.gov/pubmed/33061374
http://dx.doi.org/10.2147/IJN.S268398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533908/
https://www.ncbi.nlm.nih.gov/pubmed/33061374
http://dx.doi.org/10.2147/IJN.S268398

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