Cargando…

PSMA-Targeting Reduction-Cleavable Hyperbranched Polyamide-Amine Gene Delivery System to Treat the Bone Metastases of Prostate Cancer

OBJECTIVE: This study aimed to develop aptamer-anchored hyperbranched poly(amido amine) (HPAA) for the systemic delivery of miRNA-133a-3p and to evaluate its therapeutic potential against bone metastasis of prostate cancer in vivo and in vitro. METHODS: A glutathione (GSH)-responsive cationic HPAA w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Yongheng, Zhang, Lingli, Dai, Yuhu, Wang, Zhi, Li, Cuie, Peng, Yue, Ma, Dong, He, Peiheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533908/ https://www.ncbi.nlm.nih.gov/pubmed/33061374 http://dx.doi.org/10.2147/IJN.S268398

Ejemplares similares

Surface Functionalization of Graphene Oxide with Hyperbranched Polyamide-Amine and Microcrystalline Cellulose for Efficient Adsorption of Heavy Metal Ions
por: Liu, Zhihang, et al.
Publicado: (2022)

The Impact of Polymer Size and Cleavability on the Intravenous Pharmacokinetics of PEG-Based Hyperbranched Polymers in Rats
por: Marasini, Nirmal, et al.
Publicado: (2020)

Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery
por: Huang, Yihang, et al.
Publicado: (2014)

Synthesis and radiolabelling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers
por: Murce, Erika, et al.
Publicado: (2023)

Hyperbranched polyamide modified graphene oxide-reinforced polyurethane nanocomposites with enhanced mechanical properties
por: Liu, Yahao, et al.
Publicado: (2021)

Mapping Peptide–Protein Interactions by Amine-Reactive Cleavable Photoaffinity Reagents
por: Korovesis, Dimitris, et al.
Publicado: (2023)

Proton Conductive Channel Optimization in Methanol Resistive Hybrid Hyperbranched Polyamide Proton Exchange Membrane
por: Ma, Liying, et al.
Publicado: (2017)

Synthesis and characterization of hyperbranched poly(ester-amine) by Michael addition polymerization
por: Sun, Miao, et al.
Publicado: (2017)

Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems
por: Wang, Hao, et al.
Publicado: (2017)

Synthesis and characterization of novel functional hyperbranched polyamides from AB(2) units: effect of extra functional groups
por: Rezania, Hamidreza
Publicado: (2020)

Reduction responsive and surface charge switchable polyurethane micelles with acid cleavable crosslinks for intracellular drug delivery
por: Zhao, Lili, et al.
Publicado: (2018)

Prostate-specific membrane antigen (PSMA)-targeted photodynamic therapy enhances the delivery of PSMA-targeted magnetic nanoparticles to PSMA-expressing prostate tumors
por: Ngen, Ethel J., et al.
Publicado: (2021)

PSMA-PET Detection of Unusual Metastases in Castrate-Sensitive Prostate Carcinoma
por: Harris, Nathanial, et al.
Publicado: (2023)

A cleavable self-delivery nanoparticle for tumor photo-immunotherapy
por: Hu, Chuan, et al.
Publicado: (2021)

Cleavable ester linked magnetic nanoparticles for labeling of solvent exposed primary amine groups of peptides/proteins
por: Patil, Ujwal S., et al.
Publicado: (2015)

PSMA PET/CT to evaluate response to SBRT for prostate cancer bone metastases
por: Sadetski, Igor, et al.
Publicado: (2021)

Designing single trigger/dual-response release and degradation into amine-functional hyperbranched-polydendron nanoprecipitates
por: Rogers, Hannah E., et al.
Publicado: (2020)

Simultaneous Effects of Carboxyl Group-Containing Hyperbranched Polymers on Glass Fiber-Reinforced Polyamide 6/Hollow Glass Microsphere Syntactic Foams
por: Kim, Jincheol, et al.
Publicado: (2022)

Incidental Finding of a PSMA-Positive Pancreatic Cancer in a Patient Suffering from a Metastasized PSMA-Positive Prostate Cancer
por: Sirtl, Simon, et al.
Publicado: (2021)

(68)Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer
por: Damjanovic, Jonathan, et al.
Publicado: (2019)

Role of PSMA PET-guided metastases-directed therapy in oligometastatic recurrent prostate cancer
por: Alberto, Matthew, et al.
Publicado: (2022)

A Review: Adsorption and Removal of Heavy Metals Based on Polyamide-amines Composites
por: Wang, Qian, et al.
Publicado: (2022)

Heparin-Coated Dendronized Hyperbranched Polymers for Antimalarial Targeted Delivery
por: San Anselmo, María, et al.
Publicado: (2022)

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
por: Fang, Yan, et al.
Publicado: (2017)

Enzalutamide Enhances PSMA Expression of PSMA-Low Prostate Cancer
por: Staniszewska, Magdalena, et al.
Publicado: (2021)

Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer
por: Shi, Sheng-Jia, et al.
Publicado: (2019)

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases
por: Nomura, Natsuko, et al.
Publicado: (2014)

(68)Ga-PSMA-PET/CT for the evaluation of pulmonary metastases and opacities in patients with prostate cancer
por: Damjanovic, Jonathan, et al.
Publicado: (2018)

Remdesivir-loaded bis-MPA hyperbranched dendritic nanocarriers for pulmonary delivery
por: Halevas, Eleftherios, et al.
Publicado: (2022)

MMP-9 Responsive PEG Cleavable Nanovesicles for Efficient Delivery of Chemotherapeutics to Pancreatic Cancer
por: Kulkarni, Prajakta S., et al.
Publicado: (2014)

Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery
por: Lee, Seulgi, et al.
Publicado: (2017)

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
por: Zhao, Guanren, et al.
Publicado: (2017)

S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
por: Wang, Changping, et al.
Publicado: (2020)

Self-healing hyperbranched poly(aroyltriazole)s
por: Wei, Qiang, et al.
Publicado: (2013)

Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases?
por: Leitsmann, Conrad, et al.
Publicado: (2019)

Predicting the Risk of Metastases by PSMA-PET/CT—Evaluation of 335 Men with Treatment-Naïve Prostate Carcinoma
por: Koerber, Stefan A., et al.
Publicado: (2021)

Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy
por: Wu, Xin, et al.
Publicado: (2011)

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker
por: Prag, Hiran A., et al.
Publicado: (2020)

An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives
por: Liang, Xuan, et al.
Publicado: (2014)

Hyperbranched Polyelectrolyte Copolymers as Novel Candidate Delivery Systems for Bio-Relevant Compounds
por: Balafouti, Anastasia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sqh1vpf7hvi5ad5d71sfevkqnq