Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent against both kinases with IC(50) values 0.978 and 8...

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Detalles Bibliográficos
Autores principales: Anbar, Hanan S., El-Gamal, Mohammed I., Tarazi, Hamadeh, Lee, Bong S., Jeon, Hong R., Kwon, Dow, Oh, Chang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534351/
https://www.ncbi.nlm.nih.gov/pubmed/32962435
http://dx.doi.org/10.1080/14756366.2020.1819260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534351/
https://www.ncbi.nlm.nih.gov/pubmed/32962435
http://dx.doi.org/10.1080/14756366.2020.1819260

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