Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically lin...

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Detalles Bibliográficos
Autores principales: Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534633/
https://www.ncbi.nlm.nih.gov/pubmed/32929860
http://dx.doi.org/10.15252/embr.202050241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534633/
https://www.ncbi.nlm.nih.gov/pubmed/32929860
http://dx.doi.org/10.15252/embr.202050241

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