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Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically lin...
Autores principales: | Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534633/ https://www.ncbi.nlm.nih.gov/pubmed/32929860 http://dx.doi.org/10.15252/embr.202050241 |
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