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The eroding chromatin landscape of aging stem cells

Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accu...

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Detalles Bibliográficos
Autores principales: Shi, Changyou, Wang, Lin, Sen, Payel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534803/
https://www.ncbi.nlm.nih.gov/pubmed/33024907
http://dx.doi.org/10.1016/j.tma.2020.08.002