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The eroding chromatin landscape of aging stem cells

Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accu...

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Detalles Bibliográficos
Autores principales: Shi, Changyou, Wang, Lin, Sen, Payel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534803/
https://www.ncbi.nlm.nih.gov/pubmed/33024907
http://dx.doi.org/10.1016/j.tma.2020.08.002
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author Shi, Changyou
Wang, Lin
Sen, Payel
author_facet Shi, Changyou
Wang, Lin
Sen, Payel
author_sort Shi, Changyou
collection PubMed
description Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accumulation of damage, and altered transcriptional response. A body of work has shown that altered chromatin is a driver of cell fate changes and a regulator of self-renewal in stem cells and therefore a prime target for juvenescence therapeutics. This review focuses on chromatin changes in stem cell aging and provides a composite view of both common and unique epigenetic themes apparent from the studies of multiple stem cell types.
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spelling pubmed-75348032020-10-05 The eroding chromatin landscape of aging stem cells Shi, Changyou Wang, Lin Sen, Payel Transl Med Aging Article Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accumulation of damage, and altered transcriptional response. A body of work has shown that altered chromatin is a driver of cell fate changes and a regulator of self-renewal in stem cells and therefore a prime target for juvenescence therapeutics. This review focuses on chromatin changes in stem cell aging and provides a composite view of both common and unique epigenetic themes apparent from the studies of multiple stem cell types. 2020-08-17 2020 /pmc/articles/PMC7534803/ /pubmed/33024907 http://dx.doi.org/10.1016/j.tma.2020.08.002 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Shi, Changyou
Wang, Lin
Sen, Payel
The eroding chromatin landscape of aging stem cells
title The eroding chromatin landscape of aging stem cells
title_full The eroding chromatin landscape of aging stem cells
title_fullStr The eroding chromatin landscape of aging stem cells
title_full_unstemmed The eroding chromatin landscape of aging stem cells
title_short The eroding chromatin landscape of aging stem cells
title_sort eroding chromatin landscape of aging stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534803/
https://www.ncbi.nlm.nih.gov/pubmed/33024907
http://dx.doi.org/10.1016/j.tma.2020.08.002
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