Cargando…

Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria

The human gut symbiont Ruminococcus gnavus scavenges host-derived N-acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2,7-anhydro-Neu5Ac. We previously showed that 2,7-anhydro-Neu5Ac is transported into R. gnavus ATCC 29149 before being converted back to Neu5Ac for further metabolic pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bell, Andrew, Severi, Emmanuele, Lee, Micah, Monaco, Serena, Latousakis, Dimitrios, Angulo, Jesus, Thomas, Gavin H., Naismith, James H., Juge, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535918/ https://www.ncbi.nlm.nih.gov/pubmed/32669363 http://dx.doi.org/10.1074/jbc.RA120.014454

Ejemplares similares

Biochemical and structural basis of sialic acid utilization by gut microbes
por: Bell, Andrew, et al.
Publicado: (2023)

Structure and function of microbial α-l-fucosidases: a mini review
por: Wu, Haiyang, et al.
Publicado: (2023)

Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals
por: Severi, Emmanuele, et al.
Publicado: (2021)

Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron
por: Duan, Cheng-Jie, et al.
Publicado: (2021)

How Sweet Are Our Gut Beneficial Bacteria? A Focus on Protein Glycosylation in Lactobacillus
por: Latousakis, Dimitrios, et al.
Publicado: (2018)

Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut
por: Bell, Andrew, et al.
Publicado: (2019)

NAD(+) biosynthesis in bacteria is controlled by global carbon/nitrogen levels via PII signaling
por: Santos, Adrian Richard Schenberger, et al.
Publicado: (2020)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)
por: Yates, Christopher J., et al.
Publicado: (2014)

Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface
por: Piskol, Fabian, et al.
Publicado: (2022)

Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major
por: Ong, Han B., et al.
Publicado: (2011)

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism
por: Aertker, Kristina M.J., et al.
Publicado: (2021)

Structural and functional aspects of mannuronic acid–specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus
por: Stender, Emil G. P., et al.
Publicado: (2019)

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog
por: Nguyen, Suong, et al.
Publicado: (2013)

The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases
por: Crouch, Lucy I., et al.
Publicado: (2016)

ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites
por: Randak, Christoph O., et al.
Publicado: (2013)

Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous β-actin in vitro
por: Pathan-Chhatbar, Salma, et al.
Publicado: (2018)

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase
por: Blazer, Levi L., et al.
Publicado: (2016)

Energy Landscapes and Catalysis in Nitric-oxide Synthase
por: Sobolewska-Stawiarz, Anna, et al.
Publicado: (2014)

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism
por: Acquistapace, Isabella M., et al.
Publicado: (2020)

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
por: Karkare, Shantanu, et al.
Publicado: (2013)

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE
por: Hernandez-Ortega, Aitor, et al.
Publicado: (2014)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein
por: Eram, Mohammad S., et al.
Publicado: (2014)

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives
por: Monestier, Marie, et al.
Publicado: (2017)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
por: Singleton, Rachelle S., et al.
Publicado: (2011)

Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44
por: Ariza, Antonio, et al.
Publicado: (2011)

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex
por: Vorontsov, Ivan I., et al.
Publicado: (2011)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities
por: Bloemink, Marieke J., et al.
Publicado: (2011)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
por: Szeto, Mindy D., et al.
Publicado: (2011)

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
por: Ishizuka, Tomoko, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_euhclghejbtng245cn9t10g9g9