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c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal cells to maintain tissue homeostasis: c-Myc induces the expression of ARF tumor suppressor (p14(ARF) in human and p19(...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536215/ https://www.ncbi.nlm.nih.gov/pubmed/33020477 http://dx.doi.org/10.1038/s41467-020-18735-8 |