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Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding
Saturation-transfer difference (STD) NMR spectroscopy is a fast and versatile method which can be applied for drug-screening purposes, allowing the determination of essential ligand binding affinities (K(D)). Although widely employed to study soluble proteins, its use remains negligible for membrane...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536232/ https://www.ncbi.nlm.nih.gov/pubmed/33020522 http://dx.doi.org/10.1038/s41598-020-73443-z |