In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents

5-fluorouracil (5-FU) has been shown to have suffered from resistance which demands a solution entailing the development of 5-FU analogues. Our study aims to design a number of analogues of 5-FU and evaluate their effectiveness against thymidylate synthase (TS) in silico compared to parent 5-FU with...

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Detalles Bibliográficos
Autores principales: Chowdhury, Surid Mohammad, Hossain, Md. Nuruzzaman, Rafe, Md. Rajdoula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536301/
https://www.ncbi.nlm.nih.gov/pubmed/33033767
http://dx.doi.org/10.1016/j.heliyon.2020.e04978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536301/
https://www.ncbi.nlm.nih.gov/pubmed/33033767
http://dx.doi.org/10.1016/j.heliyon.2020.e04978

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