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In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents
5-fluorouracil (5-FU) has been shown to have suffered from resistance which demands a solution entailing the development of 5-FU analogues. Our study aims to design a number of analogues of 5-FU and evaluate their effectiveness against thymidylate synthase (TS) in silico compared to parent 5-FU with...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536301/ https://www.ncbi.nlm.nih.gov/pubmed/33033767 http://dx.doi.org/10.1016/j.heliyon.2020.e04978 |