Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder caused by CAG expansion in the HTT gene. In this study, we thoroughly investigated mitochondrial-based mechanisms in HD patient-derived iPSC (...

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Detalles Bibliográficos
Autores principales: Lopes, Carla, Tang, Yang, Anjo, Sandra I., Manadas, Bruno, Onofre, Isabel, de Almeida, Luís P., Daley, George Q., Schlaeger, Thorsten M., Rego, Ana Cristina Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536317/
https://www.ncbi.nlm.nih.gov/pubmed/33072759
http://dx.doi.org/10.3389/fcell.2020.576592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536317/
https://www.ncbi.nlm.nih.gov/pubmed/33072759
http://dx.doi.org/10.3389/fcell.2020.576592

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