Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the genetic evidence supporting GIPR antagonism, we pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Killion, Elizabeth A., Chen, Michelle, Falsey, James R., Sivits, Glenn, Hager, Todd, Atangan, Larissa, Helmering, Joan, Lee, Jae, Li, Hongyan, Wu, Bin, Cheng, Yuan, Véniant, Murielle M., Lloyd, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536395/
https://www.ncbi.nlm.nih.gov/pubmed/33020469
http://dx.doi.org/10.1038/s41467-020-18751-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536395/
https://www.ncbi.nlm.nih.gov/pubmed/33020469
http://dx.doi.org/10.1038/s41467-020-18751-8

Ejemplares similares