Hepatic NADH reductive stress underlies common variation in metabolic traits

The cellular NADH/NAD(+) ratio is fundamental to biochemistry but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here, we report the in vivo application of LbNOX(1), a bacterial water-forming NADH oxidase, to assess the metabolic consequences of dire...

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Detalles Bibliográficos
Autores principales: Goodman, Russell P., Markhard, Andrew L., Shah, Hardik, Sharma, Rohit, Skinner, Owen S., Clish, Clary B., Deik, Amy, Patgiri, Anupam, Hsu, Yu-Han, Masia, Ricard, Noh, Hye Lim, Suk, Sujin, Goldberger, Olga, Hirschhorn, Joel, Yellen, Gary, Kim, Jason K., Mootha, Vamsi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536642/
https://www.ncbi.nlm.nih.gov/pubmed/32461692
http://dx.doi.org/10.1038/s41586-020-2337-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536642/
https://www.ncbi.nlm.nih.gov/pubmed/32461692
http://dx.doi.org/10.1038/s41586-020-2337-2

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