SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects in viral pathogenesis and transmission remain unclear. We engineered SARS-CoV-2 variants harboring the D614G substitution with or without nanoluciferase. The D614G variant replicates mor...

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Detalles Bibliográficos
Autores principales: Hou, Yixuan J., Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, Kenneth H, Leist, Sarah R., Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E., Mascenik, Teresa M., Edwards, Caitlin E., Tse, Longping V., Boucher, Richard C., Randell, Scott H., Suzuki, Tadaki, Gralinski, Lisa E., Kawaoka, Yoshihiro, Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536872/
https://www.ncbi.nlm.nih.gov/pubmed/33024969
http://dx.doi.org/10.1101/2020.09.28.317685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536872/
https://www.ncbi.nlm.nih.gov/pubmed/33024969
http://dx.doi.org/10.1101/2020.09.28.317685

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