Liver X receptors are required for thymic resilience and T cell output

The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)—a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity—critically contribute to thymic integrity and function. LXRαβ-deficien...

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Detalles Bibliográficos
Autores principales: Chan, Christopher T., Fenn, Ashley M., Harder, Nina K., Mindur, John E., McAlpine, Cameron S., Patel, Jyoti, Valet, Colin, Rattik, Sara, Iwamoto, Yoshiko, He, Shun, Anzai, Atsushi, Kahles, Florian, Poller, Wolfram C., Janssen, Henrike, Wong, Lai Ping, Fernandez-Hernando, Carlos, Koolbergen, David R., van der Laan, Anja M., Yvan-Charvet, Laurent, Sadreyev, Ruslan I., Nahrendorf, Matthias, Westerterp, Marit, Tall, Alan R., Gustafsson, Jan-Ake, Swirski, Filip K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537384/
https://www.ncbi.nlm.nih.gov/pubmed/32716519
http://dx.doi.org/10.1084/jem.20200318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537384/
https://www.ncbi.nlm.nih.gov/pubmed/32716519
http://dx.doi.org/10.1084/jem.20200318

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