Cargando…

Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes

Regulation of food intake is a recently identified endocrine function of bone that is mediated by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat mass while improving glucose metabolism. We now show that serum LCN2 levels correlate with insulin levels and β-cell fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mosialou, Ioanna, Shikhel, Steven, Luo, Na, Petropoulou, Peristera Ioanna, Panitsas, Konstantinos, Bisikirska, Brygida, Rothman, Nyanza J., Tenta, Roxane, Cariou, Bertrand, Wargny, Matthieu, Sornay-Rendu, Elisabeth, Nickolas, Thomas, Rubin, Mishaela, Confavreux, Cyrille B., Kousteni, Stavroula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537391/ https://www.ncbi.nlm.nih.gov/pubmed/32639539 http://dx.doi.org/10.1084/jem.20191261

Ejemplares similares

Lipocalin-2 is an anorexigenic signal in primates
por: Petropoulou, Peristera-Ioanna, et al.
Publicado: (2020)

A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice
por: Luo, Na, et al.
Publicado: (2022)

FoxO1-Dependent Induction of Acute Myeloid Leukemia by Osteoblasts in Mice
por: Kode, Aruna, et al.
Publicado: (2015)

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software
por: Apaolaza, Paola S., et al.
Publicado: (2021)

Improvements in Plasma Tumor Necrosis Factor-Alpha Levels after a Weight-Loss Lifestyle Intervention in Patients with Obstructive Sleep Apnea
por: Georgoulis, Michael, et al.
Publicado: (2022)

Leukemogenesis Induced by an Activating β-catenin mutation in Osteoblasts
por: Kode, Aruna, et al.
Publicado: (2014)

Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea
por: Georgoulis, Michael, et al.
Publicado: (2023)

A bone marrow niche-derived molecular switch between osteogenesis and hematopoiesis
por: Galán-Díez, Marta, et al.
Publicado: (2018)

Association of circulating microRNAs with prevalent and incident knee osteoarthritis in women: the OFELY study
por: Rousseau, Jean-Charles, et al.
Publicado: (2020)

Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia
por: Galán-Díez, Marta, et al.
Publicado: (2022)

Mapping and targeting of the leukemic microenvironment
por: Witkowski, Matthew T., et al.
Publicado: (2019)

Bone: from a reservoir of minerals to a regulator of energy metabolism
por: Confavreux, Cyrille B
Publicado: (2011)

Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma
por: Asimakopoulou, Anastasia, et al.
Publicado: (2019)

Deterioration of Cortical and Trabecular Microstructure Identifies Women With Osteopenia or Normal Bone Mineral Density at Imminent and Long‐Term Risk for Fragility Fracture: A Prospective Study
por: Chapurlat, Roland, et al.
Publicado: (2019)

Inferring Protein Modulation from Gene Expression Data Using Conditional Mutual Information
por: Giorgi, Federico M., et al.
Publicado: (2014)

Correction: Inferring Protein Modulation from Gene Expression Data Using Conditional Mutual Information
por: Giorgi, Federico M., et al.
Publicado: (2016)

Comment on Chen et al. Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication. Diabetes Care 2020;43:1399–1407
por: Cariou, Bertrand, et al.
Publicado: (2020)

Diabète et COVID-19 : les leçons de CORONADO
por: Cariou, Bertrand, et al.
Publicado: (2021)

Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture
por: Pickering, Marie-Eva, et al.
Publicado: (2019)

Exercise Counteracts the Deleterious Effects of Cancer Cachexia
por: Tsitkanou, Stavroula, et al.
Publicado: (2022)

Discovery of New 1,4,6-Trisubstituted-1H-pyrazolo[3,4-b]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer †
por: Georgiou, Maria, et al.
Publicado: (2023)

Tear Lipocalin and Lipocalin-Interacting Membrane Receptor
por: Glasgow, Ben J.
Publicado: (2021)

COVID-19 and Diabetes Outcomes: Rationale for and Updates from the CORONADO Study
por: Smati, Sarra, et al.
Publicado: (2022)

LipocalinPred: a SVM-based method for prediction of lipocalins
por: Ramana, Jayashree, et al.
Publicado: (2009)

Regulation of Glucose Handling by the Skeleton: Insights From Mouse and Human Studies
por: Liu, Jian-Min, et al.
Publicado: (2016)

Systematic, network-based characterization of therapeutic target inhibitors
por: Shen, Yao, et al.
Publicado: (2017)

Dimerization of lipocalin allergens
por: Niemi, Merja H., et al.
Publicado: (2015)

Lipocalin-2 in Stroke
por: Chou, Wen-Hai, et al.
Publicado: (2015)

Three-dimensional Cryolipolysis for Submental and Lateral Neck Fat Reduction
por: Rodopoulou, Stavroula, et al.
Publicado: (2020)

A Safe and Effective Lip Augmentation Method: The Step-by-Step Φ (Phi) Technique
por: Keramidas, Evangelos, et al.
Publicado: (2021)

Bioprinting on Organ-on-Chip: Development and Applications
por: Chliara, Maria Anna, et al.
Publicado: (2022)

A Proposed Classification and Treatment Algorithm for Rectus Diastasis: A Prospective Study
por: Keramidas, Evangelos, et al.
Publicado: (2022)

Incidence and risk factors of herpes zoster among adult renal transplant recipients receiving universal antiviral prophylaxis
por: Pavlopoulou, Ioanna D., et al.
Publicado: (2015)

Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells
por: Gioti, Katerina, et al.
Publicado: (2021)

Novel clinical, molecular and bioinformatics insights into the genetic background of autism
por: Talli, Ioanna, et al.
Publicado: (2022)

Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells
por: Yen, Bonnie, et al.
Publicado: (2018)

Lipocalins in Arthropod Chemical Communication
por: Zhu, Jiao, et al.
Publicado: (2021)

Lipocalin-2 and Cerebral Stroke
por: Luo, Chao, et al.
Publicado: (2022)

Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases
por: Xanthoulea, Sofia, et al.
Publicado: (2004)

Fracture Risk Evaluation of Bone Metastases: A Burning Issue
por: Confavreux, Cyrille B., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cmuc3igg0o7s2vuuetqeams87h