Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen

The STAT3 signaling pathway is required for early Th17 cell development, and therapies targeting this pathway are used for autoimmune disease. However, the role of STAT3 in maintaining inflammatory effector Th17 cell function has been unexplored. Th17(ΔSTAT3) mice, which delete STAT3 in effector Th1...

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Detalles Bibliográficos
Autores principales: Poholek, Catherine H., Raphael, Itay, Wu, Dongwen, Revu, Shankar, Rittenhouse, Natalie, Uche, Uzodinma U., Majumder, Saikat, Kane, Lawrence P., Poholek, Amanda C., McGeachy, Mandy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537401/
https://www.ncbi.nlm.nih.gov/pubmed/32697822
http://dx.doi.org/10.1084/jem.20191761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537401/
https://www.ncbi.nlm.nih.gov/pubmed/32697822
http://dx.doi.org/10.1084/jem.20191761

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