A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G(0)/G(1) phase and induces mitochondrial apoptosis in non-small cell lung cancer cells

BACKGROUND: A novel dual MEK/PDK1 inhibitor named 9za has been synthesized by our research team. Preliminary study showed that 9za possessed potent cytotoxicity and proapoptosis in non-small cell lung cancer (NSCLC) cells. Nevertheless, the precise underlying mechanism is vague. METHODS: In this wor...

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Detalles Bibliográficos
Autores principales: Liu, Rangru, Yu, Zutao, Chen, Zhuo, Liu, Danqi, Huang, Fengying, Li, Qianbin, Hu, Gaoyun, Yi, Xinan, Li, Xi, Zhou, Honghao, Liu, Zhaoqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537639/
https://www.ncbi.nlm.nih.gov/pubmed/33072436
http://dx.doi.org/10.7717/peerj.9981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537639/
https://www.ncbi.nlm.nih.gov/pubmed/33072436
http://dx.doi.org/10.7717/peerj.9981

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