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A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G(0)/G(1) phase and induces mitochondrial apoptosis in non-small cell lung cancer cells
BACKGROUND: A novel dual MEK/PDK1 inhibitor named 9za has been synthesized by our research team. Preliminary study showed that 9za possessed potent cytotoxicity and proapoptosis in non-small cell lung cancer (NSCLC) cells. Nevertheless, the precise underlying mechanism is vague. METHODS: In this wor...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537639/ https://www.ncbi.nlm.nih.gov/pubmed/33072436 http://dx.doi.org/10.7717/peerj.9981 |