Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...

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Detalles Bibliográficos
Autores principales: Ito, Daichi, Ge, Dan, Kogure, Noriyuki, Manaka, Hitomi, Terui, Yusuke, Takayama, Hiromitsu, Linhardt, Robert J., Toida, Toshihiko, Higashi, Kyohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538075/
https://www.ncbi.nlm.nih.gov/pubmed/33043161
http://dx.doi.org/10.1016/j.heliyon.2020.e05168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538075/
https://www.ncbi.nlm.nih.gov/pubmed/33043161
http://dx.doi.org/10.1016/j.heliyon.2020.e05168

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