Cargando…
The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
PIX proteins are guanine nucleotide exchange factors (GEFs) that activate Rac and Cdc42, and are known to have numerous functions in various cell types. Here, we show that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, we found that pix-1 is required for the...
Autores principales: | Moody, Jasmine C., Qadota, Hiroshi, Reedy, April R., Okafor, C. Denise, Shanmugan, Niveda, Matsunaga, Yohei, Christian, Courtney J., Ortlund, Eric A., Benian, Guy M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538588/ https://www.ncbi.nlm.nih.gov/pubmed/33024114 http://dx.doi.org/10.1038/s41467-020-18852-4 |
Ejemplares similares
-
Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies
por: Connor, Kate, et al.
Publicado: (2020) -
Molecular Structure of Sarcomere-to-Membrane Attachment at M-Lines in C. elegans Muscle
por: Qadota, Hiroshi, et al.
Publicado: (2010) -
Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle
por: Matsunaga, Yohei, et al.
Publicado: (2015) -
Rho Family GTPases and Rho GEFs in Glucose Homeostasis
por: Machin, Polly A., et al.
Publicado: (2021) -
Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
por: Perry, Nicole A., et al.
Publicado: (2014)