Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3(+) Tregs in vitro

Low-zone IL-2 signaling is key to understanding how CD4(+) CD25(high) FOXP3(+) regulatory T cells (Tregs) exhibit dominance and overgrow conventional effector T cells (Tcons) that typically express lower levels of the IL-2 receptor alpha chain (i.e., CD25). Thus, modalities such as low-dose IL-2 or...

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Detalles Bibliográficos
Autores principales: DeOca, Kayla B., Moorman, Cody D., Garcia, Brandon L., Mannie, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538601/
https://www.ncbi.nlm.nih.gov/pubmed/33072087
http://dx.doi.org/10.3389/fimmu.2020.541619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538601/
https://www.ncbi.nlm.nih.gov/pubmed/33072087
http://dx.doi.org/10.3389/fimmu.2020.541619

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